preventive effect of coriandrum sativum on neuronal damages in pentylentetrazole-induced seizure in rats

objective:coriandrum sativum (c. sativum) as a medicinal plant has been pointed to have analgesic, hypnotic and anti-oxidant effects. in the current study, a possible preventive effect of the hydro-alcoholic extract of the plant on neuronal damages was examined in pentylenetetrazole (ptz) rat model of seizure.materials and methods: forty male rats were divided into five main groups and treated by (1) saline, (2) ptz: 100 mg/kg ptz (i.p) and (3-5) 50, 100 and 200 mg/kg of hydro-alcoholic extract of c. sativum during seven consecutive days before ptz injection. after electrocorticography (ecog), the brains were removed to use for histological examination.results:  all doses of the extract reduced duration, frequency and amplitude of the burst discharges while prolonged the latency of the seizure attacks (p<0.05, p<0.01, and p<0.001). administration of all 3 doses of the extract significantly prevented from production of dark neurons (p<0.01, and p<0.001) and apoptotic cells (p<0.05, p<0.01, and p<0.001) in different areas of the hippocampus compared to ptz group.conclusion: the results of this study allow us to conclude that c. sativum,because of its antioxidant properties, prevents from neuronal damages in ptz rat model of seizure.